Heh heh heh, how's about a little Toxic Shock Syndrome? XD For that, you'd need to:

Take a drink every time HK calls someone a meatbag.
Take two if someone asks him why he does that.

Here's a few others:

Take a drink every time Eddie Brock has gay thoughts about Spidey.
Take a drink everytime the bright lights are starting to give Recluse a headache.
For a rare one (perhaps for those who have to drive somewhere?), take a drink every time Captain Jack doesn't hit on someone.
Take a drink every time I forget that Logan still has a knife. DX
Take a drink every time Hitsugaya admonishes Fowl for something.
Two if it's unjustified.
Take a drink every time River utters a contextually coherent sentence that isn't some sort of riddle or metaphor.
Take a drink every time Wolverine gets into a fight/goes berserk as a result of someone else getting hurt.
Two if it's a kid.
Three if it's a female kid.
Four if it's a potential love interest (although there are no suitors...yet)
Drain the bottle if that person is killed.
Pop open another one and drain that too if he's the one who kills them.

Ok, I'm getting out of hand here. XD